Furthermore, Rennie strongly reduced the activity of mucosa-damaging pepsin during the period of increased pH. In contrast, the maximum pH with placebo was 1.28 during the entire gastric simulation. The maximum pH of 5.24 was maintained for almost 10 min. ResultsĪfter addition of Rennie, the gastric medium reached a pH of 3.0 within 40 s. Secondary objective: to evaluate pepsin activity over the entire 2-h gastric incubation. Primary objectives: to evaluate the time required to achieve pH 3.0, 3.5, 4.0 and 4.5, as well as the maximum pH reached. Both Rennie and placebo were dosed at two tablets per incubation over six independent, 2-h stomach incubations each. The validated Simulator of the Human Intestinal Microbial Ecosystem apparatus (SHIME, ProDigest, Belgium) was used, comprising five reactors simulating different parts of the human gastrointestinal tract. Therefore, we carried out an in vitro study comparing Rennie and placebo under simulated conditions of the human stomach (artificial stomach model) to reconfirm the onset of action of Rennie. However, published studies on their onset of action are scarce. Calcium carbonate antacids are potent over-the-counter antacids, made more effective by adding magnesium carbonate (as in Rennie, Bayer).
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